Hyperhomocysteineamia (hHcys) is thought to be a risk factor for cardiovascular disease. The epigenetic (protein) pattern due to the effect of  hHcys  in kidney and liver was profiled in thesupplemented developing rats. A group treated with 0.6 % Hcys for 8 weeksand trimethylglycine (Tri or Betaine)antioxidant treated group (6 g / Kg) were compared with four weeks age control group. The results indicated that, a great variety in protein pattern was obtained. Specific type of protein with M.W. of 214.29 K. d. was produced in the kidney samples treated with Trimethylglycine. Common types of protein with M.W. of 278.64, 157.07, 52.39, 39.31, 29.24, 24.49, 20.86, 20 and 18.87 K. d. were obtained in the same sample. Characteristic band with 59.58 K. d. was obtained in control the kidney after 8 weeks while three types of protein were obtained in the control liver with M.W. of 221.4, 28.25 and 18.07 K.d. The highest similarity index was between control and Trimethylglycine treated kidney group (0.76), but the lowest one was between the control and liver trimethylglycine treated group (0.38).