The Present work investigates the serum levels of glucose, cholesterol, protein, urea, creatinine and some enzyme activities (AST,ALT and ALP) in male albino rats treated orally with 1/10 LD50dose of thiodicarb insecticide (carbamate group)daily for 7 days (short-term) and 30days (long-term). A highly significant elevation in serum urea, creatinine, AST and ALT accompanied by a highly significant decrease in the body weight and a significant increase in serum glucose level were recorded in rats of long-term group. While, the short-term group showed a highly significant increase in serum level of glucose and urea. Moreover, a significant decrease in serum cholesterol content was recorded but the total protein concentration and ALP activity were not affected.