Field evaluation of sequence control sprays were carried out at Abou-Hamad district, Sharkia Governorate, Egypt in  the two successive cotton growing seasons 2008 and 2009 against cotton bollworms, Pectinophora gossypiella (Sound.),  Earias insulana (Boisd.) and Heliothis armigera  (Hüb.) infesting cotton green bolls as well as some sucking pests and some important predators. The seasonal average reductions in cotton bollworms infestation attained 66.67 and 61.18 % in 2008 and 2009 seasons. Conventional insecticides mixture IGRs treatments attained 91.82 and 84.42 % in 2008 season of Nezara viridula and Tetranychus spp.; 90.13 and 75.38% of N. veridula and Aphids in 2009 season, respectively. The lowest mean numbers of insects were 0.78 and 1.48 insects/week of Tetranychus spp. and N. viridula  in 2008; 0.41 and 3.33 individuals/week in 2009 season in treatments of true spiders and N. viridula  compared with untreated plots recorded 0.96 and 1.48 in 2008 season  of true spiders and N. viridula, while in 2009 the lowest mean numbers were 1.26 and 7.93 individuals/week of Tetranychus spp. and N. viridula. The tested programs resulted in the highest degree of % reduction for all investigated predators except for Chrysoperla carnea attained 99.54 ,94.05 and 91.89 % of Peaderus alfierii, Coccinella  spp. and Scymnus  spp. in 2008.In 2009 seasons the highest reduction were 100.00, and 84.30 % of Coccinella  spp. and Scymnus  spp. The insect predators (Chrysoperla carnea, Coccinella  spp. Orious  spp., Peaderus alfierii, Scymnus  spp., and true spiders) were influence significant and insignificant  relationship in the two seasons and ranged between positive & negative relationship. On the other hand, results indicate that the all predators affect sucking pests with 29.73, 32.54; 35.57,83.22; 61.88,83.54; 49.14,46.26 and 52.46,58.26% mutable regression values of  Aphis gossypii, B. tabaci, Emboasca lybica, N. viridula and Tetranychus spp. during 2008  and 2009, respectively.