The current work was carried out to evaluate the biological effects of five insect growth regulators; applaud (buprofezin), consult (hexaflumuron) and match (lufenuron) as chitin synthesis inhibitors (CSIs), mimic (tebufenozide) as ecdysone agonist (EA) and admiral (pyriproxyfen) as juvenile hormone analogue (JHA) against the housefly M. domestica. The IGRs were applied by feeding the 1^st instar larvae on diets mixed with the selected IGRs at different concentrations (10, 100, 1000 and 2000 ppm). The results demonstrated that mimic and admiral were the most effective compounds and induced 100 % larval mortalities at 2000 ppm. Mimic was the most toxic compound and its toxicity index was 100.The tested IGRs induced a significant prolongation in the larval and pupal duration.The percent pupation was highly decreased compared to the control. All the tested IGRs induced a reduction in the pupal weight as well as a reduction in the adult emergence, which was completely inhibited at 1000, and 2000 ppm. All the tested IGRs caused a significant decrease on the longevity of both sexes as compared to the control. The fecundity and fertility greatly decreased and the sterility increased with the all tested IGRs. Admiral was more effective than the others.