The efficiency of chitin synthesis inhibitor (Lufenuron), ethanolic and acetonic extracts of rice bran (Oryza sativa) were evaluated against Musca domestica eggs by direct application using topical, dipping technique and by treating vitellogenic females by both compounds. Treatment of females with different concentrations of both compounds significantly reduce egg hatchability and the effect is dose dependent. The inhibition of egg hatching increased with increase in concentration of the compound.  Direct application of both compounds to newly laid eggs (0-15 min) of Musca domestica proved to be more effective in reducing egg hatchability especially when using dipping technique. Percentage total inhibition reached 93.04±0.57 at 3 ppm for Lufenuron and 100% total inhibition at 200 ppm of acetonic extract of rice bran (Oryza sativa). This data confirm the efficiency of growth regulator derived from Oryza sativa straw and chitin synthesis inhibitor (Lufenuron). The results indicated that the acetonic extract of rice bran is significantly effective in preventing hatching than that of ethanolic extract. This is explained that the less polar the extract (acetonic) of rice bran, the more its effectiveness against eggs.