Field experiments were carried out at the Agricultural Research station, Qualiobeya Governorate during two successive seasons (Summer and Nile Plantation) to investigate the effect of different fertilizers on the squash infestation by different piercing sucking pests and on the resultant yield. Moreover the efficacy of four chemical acaricides (Ortus super, Arrow, Killmite and Vertimec) and two predaceous mites {Phytoseiulus persimilis (Athias–Henriot)and Amblyseius gossypii (El-Badry)against phytophagous mites, Tetranych usurticae Koch,and T. cucurbitacearum (Sayed)  atQualiobeya Governorate. Results showed that squash yielded by the Mixture treatment (NPK) fertilizer was higher than other fertilizers in the two seasons and the reduction percentage recorded by using Ortus super and killmite approches that of  P. persimilis.