Family Anobiidae or death-watch beetles is a coleopteran woody-injurious important family joined to superfamily Bostrichoidae which mainly devastates wooden articles and furniture and its products. Through this study a survey for these wood boring pests was undertaken in 8 Egyptian governorates; Alexandria, Damietta, Fayoum, Giza, Ismailia, Matrouh, Port Said and Sohag representing 5 different geographical regions of Egypt and 30 locations were visited at those governorates for that investigation. Two coleopterous anobiid boring beetles; the furniture beetle, Anobium punctatum (DeGeer) and the death-watch beetle, Nicobium castaneum (Olivier) were recognized in 16 and 8 surveying localities, respectively and their damage and infestation levels were determined. Laboratory screening experiments were provided with tested preparations of crude extracts of neem seeds Azadirachta indica A. Juss (Sapindales: Meliaceae), commercial Neemazal and Cidial pesticide for both remedial and protective targets. Neem extracts were mainly generated from organic solvents such ethanol and petroleum ether. Percentages of mortality and repellency rates were observed. A significant high protection level was achieved scoring 79.3 and 81.3 % for A. punctatum and N. castaneum, respectively while average mortality rates were 83.6 and 85.3 % for these two anobiids, respectively. Results of the laboratory tests encouraged a series of applied trials at the natural attacked localities to be undertaken comparing their efficiency.