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11977

Comparative Modelling, Toxicological and Biochemical Studies of Imidacloprid and Thiamethoxam Insecticides on the House Fly, Musca domestica L. (Diptera: Muscidae)

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Last updated: 03 Jan 2025

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Abstract

Neonicotinoid baits are recently replacing anticholinesterase baits for adult house fly (Musca domestica L.) control. Recently, imidacloprid (IMI) and thiamethoxam (THIA) are widely used for the control of this pest. In this study both compounds were docked to elucidate their interactions with acetylcholine binding protein (AChBP). The feeding technique was used to evaluate the toxicity of tested insecticides to adult house flies. Bioassay experiments showed that the THIA was more toxic to adult house flies than IMI with LC50 values 7.27 and 21.08 ppm; respectively. The biochemical activities of acetylcholinesterase, ATPase, cytochrome P-450 and carboxylesterase were increased by insecticides treatment, while, the total protein content was reduced.

DOI

10.21608/eajb.2018.11977

Keywords

Neonicotinoid baits, Anticholinesterases, House flies, (AChBP) and Docking

Authors

First Name

Doaa

Last Name

Abdel-Haleem

MiddleName

R.

Affiliation

Entomology Department, Faculty of Science, Ain Shams University, Cairo, Egypt.

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Orcid

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First Name

Noha

Last Name

Genidy

MiddleName

A.

Affiliation

Entomology Department, Faculty of Science, Ain Shams University, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Adel

Last Name

Fahmy

MiddleName

R.

Affiliation

Entomology Department, Faculty of Science, Ain Shams University, Cairo, Egypt.

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City

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Orcid

-

First Name

Fatma

Last Name

Abu- El Azm

MiddleName

S. M.

Affiliation

Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt

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-

City

-

Orcid

-

First Name

Nasser

Last Name

Ismail

MiddleName

S. M.

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt

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Volume

11

Article Issue

1

Related Issue

2182

Issue Date

2018-02-01

Receive Date

2018-01-03

Publish Date

2018-02-01

Page Start

33

Page End

42

Print ISSN

1687-8809

Online ISSN

2090-0813

Article File

EAJBSA_Volume 11_Issue 1_Pages 33-42.pdf

PDF . 322.1kB

Link

https://eajbsa.journals.ekb.eg/article_11977.html

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https://eajbsa.journals.ekb.eg/service?article_code=11977

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Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences. A, Entomology

Publication Link

https://eajbsa.journals.ekb.eg/

MainTitle

Comparative Modelling, Toxicological and Biochemical Studies of Imidacloprid and Thiamethoxam Insecticides on the House Fly, Musca domestica L. (Diptera: Muscidae)

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Article

Created At

22 Jan 2023