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182694

Selenium Nephroprotection through Inhibition of PERKEIF2α- CHOP Pathway in Lead Intoxicated Male Rats

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Last updated: 22 Jan 2023

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Abstract

Background: Lead contamination has turned into a major concern as it serves no useful purpose in the human body. Its presence in the body can lead to toxic effects on different organs. Aim: The purpose of the present study is to examine the efficacy of selenium in mitigating leadinduced oxidative stress and kidney injury in male albino Wistar rats. Further to study the underlying molecular mechanism. Methods: We hypothesized that selenium protect against lead nephrotoxicity by testing various parameters of kidney function in male rats treated for 28 days with o.5 mg/kg selenium versus control male rats that received a vehicle. Results: The results showed an increase of serum urea, creatinine, uric acid and urinary albumin in rats intoxicated with lead compared to control group. The increase of these parameters would indicate renal toxicity which is confirmed by histopathological changes. Lead intoxicated rats had significant increment in apoptosis as well as phosphorylated PERK, eIF2α and apoptotic proteins as CHOP, caspase 3 and 8 in the kidneys, which were attenuated by selenium treatment. Conclusion: This study clearly demonstrated that activation of PERK- eIF2α -CHOP signaling pathway was involved in lead induced nephrotoxicity in rats and selenium inhibited lead nephrotoxicity partly through suppression of PERK- eIF2α CHOP pathway.

DOI

10.21608/ajfm.2021.182694

Keywords

Lead nephrotoxicity, selenium, nephroprotection, PERK, eIF2α, CHOP pathway, Caspase

Authors

First Name

Marwa

Last Name

Rashed

MiddleName

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Affiliation

Crime Investigation Research Department, National Center for Social and Criminological Research, Cairo Egypt

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First Name

Mangoud

Last Name

El Wakel

MiddleName

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Affiliation

Environmental Research Department, National Center for Social and Criminological Research, Cairo Egypt.

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First Name

Mohammed

Last Name

Hussin

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Affiliation

Environmental Research Department, National Center for Social and Criminological Research, Cairo Egypt.

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Orcid

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First Name

Wesam

Last Name

EL Bakly

MiddleName

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Affiliation

Pharmacology Department, Faculty of Medicine, Ain Shams University, Cairo Egypt.

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Volume

37

Article Issue

2

Related Issue

24869

Issue Date

2021-07-01

Receive Date

2021-07-08

Publish Date

2021-07-01

Page Start

107

Page End

115

Print ISSN

1687-1030

Online ISSN

2636-3356

Link

https://ajfm.journals.ekb.eg/article_182694.html

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https://ajfm.journals.ekb.eg/service?article_code=182694

Order

12

Type

Original Article

Type Code

665

Publication Type

Journal

Publication Title

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

Publication Link

https://ajfm.journals.ekb.eg/

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Article

Created At

22 Jan 2023