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43103

Assessment of Acute Antipsychotic Poisoned Cases Admitted to Tanta University Poison Control Unit

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Last updated: 22 Jan 2023

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Abstract

Background: Sedative hypnotic/antipsychotic poisoning represented 5.84% of cases according to national poison data system in 2017. In Egypt, studies about antipsychotic poisoning are scarce. Objectives: is to assess the pattern of toxicity and prognosis of cases with acute antipsychotic poisoning admitted to Tanta University Poison Control Unit.
Patients and Methods: This study was conducted on cases who admitted to Tanta University Poison Control Unit with acute antipsychotics poisoning. All cases were subjected to clinical evaluation, laboratory investigations and electrocardiogram. Severity was assessed by poison severity score. Results: Majority of cases were represented equally in age groups (0-10) and (11-20) years with 33.3% for each age group, 65% of cases were females, most of cases were from urban areas (71.7%) and singles (71.7%). History of mental disorder found in 31.6% of cases and suicidal attempts represented the most common manner of poisoning (71.7%). Clozapine was the highest antipsychotic drug taken (35%) and 6.7% of cases developed extrapyramidal manifestations. Miosis was found in 56.7% of cases. Tachycardia was recorded in 46.7% of cases and QTc interval was prolonged in 43% of cases. According to poison severity score, most studied cases were either mild (51.7%) or moderate (33.7%). One case was admitted to ICU. Multiple regression analysis showed that decreased GCS, PCO2, O2 saturation were associated with increased hospital stay.
Conclusion: Antipsychotic poisoning was commonly mild to moderate. Neurological and cardiovascular manifestations were the predominant. Sinus tachycardia and prolonged QTc were the most common electrocardiographic changes. Antipsychotic poisoning usually had a good prognosis. 

DOI

10.21608/ajfm.2019.43103

Keywords

Antipsychotics, accidental poisoning, suicidal poisoning

Authors

First Name

Marwa

Last Name

Mubarak

MiddleName

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Affiliation

Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Tanta University, Tanta, Egypt.

Email

marwanemo1991@gmail.com

City

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Orcid

-

First Name

Enas

Last Name

El Madah

MiddleName

-

Affiliation

Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Tanta University, Tanta, Egypt.

Email

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City

-

Orcid

-

First Name

Doaa

Last Name

El Gharbawy

MiddleName

-

Affiliation

Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Tanta University, Tanta, Egypt.

Email

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City

-

Orcid

-

First Name

Magdy

Last Name

Ashmawy

MiddleName

-

Affiliation

Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Tanta University, Tanta, Egypt.

Email

magdyashmawy@gmail.com

City

-

Orcid

-

Volume

33

Article Issue

2

Related Issue

4955

Issue Date

2019-07-01

Receive Date

2019-07-31

Publish Date

2019-07-01

Page Start

113

Page End

125

Print ISSN

1687-1030

Online ISSN

2636-3356

Article File

AJFM_Volume 33_Issue 2_Pages 113-125.pdf

PDF . 1.1MB

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https://ajfm.journals.ekb.eg/article_43103.html

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https://ajfm.journals.ekb.eg/service?article_code=43103

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Original Article

Type Code

665

Publication Type

Journal

Publication Title

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

Publication Link

https://ajfm.journals.ekb.eg/

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Article

Created At

22 Jan 2023