Poisoning is a great problem affecting people in the all age stages and may lead to death, disease or disability, which may continue throughout the life. Methods: Retrospective study in the Forensic Medicine Laboratory Institute in Upper Egypt from 2005 to 2010. Age, sex, residence and type of poisons were analyzed to determine the toxicity pattern in this area. Results: the study revealed that the toxicity is more common in males than females (62.5% and 37.5% respectively). Age distribution of toxicity is (30 - Conclusion: Pesticides exposure and drug abuse are two big problems in our community. Drug abuse is a growing problem should be dealt with quickly because it affects the youth group.