Objectives: Thermal injuries still occur frequently in many parts of the world. Severe cutaneous thermal injuries are associated with multiple organ dysfunctions, which demand urgent medical interventions to ensure patient's survival. This failure of different organ systems can be attributed to uncontrolled production of inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), interleukin 1beta (IL-1β). The purpose of this study was to detect the effects of scald injuries on liver and brain of adult male albino rats at 6, 12 and 24 hours post injury. Material and methods: Fifty four adult male albino rats were equally divided into three groups: group I (negative control group), group II (sham group) and group III (scald injured group) effects of scald injuries on liver and brain at 6, 12 and 24 hours post injury were studied through: estimation of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and Alkaline phosphatase (ALKP) levels and histopathological examination using light microscope including HandE stained sections and immunohistochemical staining of sections for detection of (TNF-α) activity.Results: In group III (scald injured group), a markedly affected and disturbed liver functions represented by significant increases in serum AST, ALT and ALKP levels, histopathological changes were (aggregations of inflammatory cells,  congestion and dilatation of blood vessels, vaculated hepatocytes  with darkly stained nucleui and  hydropic degeneration) and ( shrunken neurons with pyknotic nuclei, vacuolated cytoplasm and edema) .Time dependent TNF-α activation was detected  in liver and brain at 6 h post injury lasting till 24h.Conclusion: From the previous results it can be concluded that, scald injury induced a marked affection and disturbance in liver functions, as characterized by significant increases in serum ALT, ASTand ALKP, histopathological changes in liver and brain . Also, a time dependent TNF-α activation was detected in liver and brain of adult male albino rats.