Cadmium (Cd) is a common environmental pollutant associated with many industrial processes. Considering the high sensitivity of the testicular tissue to Cd insult, prevention and/or therapeutic intervention is of major concern. Previous experimental evidences indicated the involvement of oxidative stress in Cd-mediated tissue damage. The present study investigated the protective role of Nigella Sativa Oil (NSO) against the toxic effect of cadmium chloride (CdCl₂) on rat testes.Forty adult male albino rats weighing 240-280 g were assigned into four groups: Group I(Control rats), Group II (NSO-treated rats), Group III (CdCl₂-treated rats) and Group IV(rats treated with CdCl₂ and NSO). Cadmium chloride was injected in a dose of 2mg/kg bw dissolved in isotonic saline intraperitoneal, whileNSO was administered in a dose of 1 ml/kg bwby gastric gavage.The present study found that administration of CdCl₂ induced marked structural derangement in the seminiferous tubules of the rats' testes associated with significant drop of spermatogenesis score. Concomitant administration of NSO and CdCl₂ was associated with markedreduction in the adverse structural changes seen in the testes of CdCl₂-intoxicated ratsbesides preservation of spermatogenesis.