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18731

HIV-1 RT-Associated RNase H review

Article

Last updated: 03 Jan 2025

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Tags

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Abstract

HIV-RT is an essential enzyme for HIV replication it comprises two associated functions: RNA- and DNA-dependent DNA polymerase (RDDP & DDDP) and ribonuclease H (RNase H). The RNase H is function to cleave RNA strand in RNA/DNA hybrid intermediate in the reverse transcription process. Currently, successful inhibitors target the polymerase function of HIV-RT. RNase H evolves to be a promising target for anti-HIV drug research. This review describes the compounds reported as HIV-1 RNase H inhibitors.

DOI

10.21608/aps.2018.18731

Keywords

HIV-1, ribonuclease H, reverse transcriptase, tropolone, hydrazone

Authors

First Name

Madonna

Last Name

Mitry

MiddleName

M. A.

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt

Email

madonna.michael@pharma.asu.edu.eg

City

-

Orcid

-

First Name

Nermin

Last Name

Abdou

MiddleName

S.

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt

Email

nerminsamir@pharma.asu.edu.eg

City

-

Orcid

0000-0002-8654-5540

First Name

Rabah

Last Name

Serya

MiddleName

A. T.

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt

Email

rabah@pharma.asu.edu.eg

City

-

Orcid

-

Volume

2

Article Issue

1

Related Issue

2032

Issue Date

2018-01-01

Receive Date

2018-02-08

Publish Date

2018-06-01

Page Start

22

Page End

30

Print ISSN

2356-8380

Online ISSN

2356-8399

Article File

APS_Volume 2_Issue 1_Pages 22-30.pdf

PDF . 641.2kB

Link

https://aps.journals.ekb.eg/article_18731.html

Detail API

https://aps.journals.ekb.eg/service?article_code=18731

Order

3

Type

Review Article

Type Code

658

Publication Type

Journal

Publication Title

Archives of Pharmaceutical Sciences Ain Shams University

Publication Link

https://aps.journals.ekb.eg/

MainTitle

HIV-1 RT-Associated RNase H review

Details

Type

Article

Created At

22 Jan 2023