Hepatoprotective activity was measured for Erythrina crista-galli extract as well as fractions. Fractions II and III have shown a remarkable protective effect against CCl₄-induced hepatocyte injury. This was evidenced by their ability to significantly ameliorate CCl₄-induced elevation in ALT and AST levels. This is supported by the notion that pretreatment of hepatocytes with either Erythrina crista-galli extracts or fractions significantly alleviated CCl₄- induced GSH and SOD depletion and replenished CCL₄ reduction of TAC. Hepatoprotective activity mechanism is attributed at least in part, to the free radical scavenging and antioxidant activity of the phenolic compounds present in the extract proved by the phytochemical screening of the fractions.