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275777

Synthesis and antimicrobial study of new tetrazole, benzimidazole and N3-functionalized quinazolinone derivatives

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Last updated: 03 Jan 2025

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Abstract

Reactions of 4H-3,1-benzoxazin-4-one 3 with various nitrogen nucleophiles; sodium azide, hydroxylamine hydrochloride, ammonium acetate, and formamide afforded new N-heterocyclic compounds 4-7. The synthesized quinazolinone derivative 7 was used as a useful building block for further synthesis of new series of N3-functionalized quinazolinone compounds 8-12. The chemical structures of all synthesized heterocyclic compounds were deduced from their spectroscopic analyses. The antimicrobial activity of the new compounds was evaluated against several pathogenic microorganisms, and most of them showed remarkable activity comparable to the antibacterial Ciprofloxacin and antifungal Clotrimazole.

DOI

10.21608/jsrs.2022.275777

Keywords

Benzoxazinone, Quinazolinone, Benzimidazole, Tetrazole, antimicrobial activity

Authors

First Name

Dina

Last Name

G. Sanad

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-

Affiliation

Chemistry Department, Faculty iof Women for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo 11757, Egypt.

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First Name

Ahmed

Last Name

S.A. Youssef

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-

Affiliation

Chemistry Department, Faculty of Science, Ain Shams University, Abasia, Cairo 11566, Egypt.

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Orcid

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First Name

Fatma

Last Name

A. El-Mariaha

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-

Affiliation

Chemistry Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo 11757, Egypt.

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Orcid

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First Name

Heba

Last Name

E. Hashem

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-

Affiliation

Chemistry Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo 11757, Egypt.

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Volume

39

Article Issue

1

Related Issue

38372

Issue Date

2022-12-01

Receive Date

2022-12-24

Publish Date

2022-12-01

Page Start

83

Page End

103

Print ISSN

2356-8364

Online ISSN

2356-8372

Article File

JSRS_Volume 39_Issue 1_Pages 83-103.pdf

PDF . 1.9MB

Link

https://jsrs.journals.ekb.eg/article_275777.html

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https://jsrs.journals.ekb.eg/service?article_code=275777

Order

275,777

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Original Article

Type Code

656

Publication Type

Journal

Publication Title

Journal of Scientific Research in Science

Publication Link

https://jsrs.journals.ekb.eg/

MainTitle

Synthesis and antimicrobial study of new tetrazole, benzimidazole and N3-functionalized quinazolinone derivatives

Details

Type

Article

Created At

22 Jan 2023