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210692

Albumin nanoparticles Preparation, Characterization and In-Vitro Safety Evaluation

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Last updated: 22 Jan 2023

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Abstract

The goal of this study was to prepare and characterize albumin nanoparticles to be later used as a drug delivery system. The utilization of nanoparticles as a delivery system for antimicrobial drugs has arisen recently which solve many problems and enhance the traditional treatment with this antimicrobial drugs. In this study, nanoparticles of bovine serum albumen were successfully obtained using a coacervation process (separation of proteins in two liquid phases in colloidal systems).  The prepared nanoparticles were nearly spherical in shape and have smooth surface as determined by Transmission Electron Microscopy (TEM). The sizes of the obtained nanoparticles were 70 ± 10 nm with negative surface zeta potential. Additionally, the in vitro safety of albumin nanoparticles has been demonstrated. Both cytotoxicity and genotoxicity studies indicated that, there is no observed toxic effect of nano-albumin on lymphocyte cell line. Also, the results showed that the albumin nanoparticles enhances and promotes the response of immune system.

DOI

10.21608/jsrs.2021.210692

Keywords

albumin nanoparticles, cytotoxic, Genotoxic, proliferation activity

Authors

First Name

dina

Last Name

youssef

MiddleName

galal

Affiliation

Biotechnology Unit Animal Reproduction Research Institute (ARRi)

Email

dndn_77777@yahoo.com

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First Name

Fatma A.

Last Name

Sallam

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-

Affiliation

Faculty of Women for Arts, Science and Education, Ain Shams University, Egypt.

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Orcid

-

First Name

Taher A.

Last Name

Salaheldin

MiddleName

-

Affiliation

Nanotechnology and Advanced Material Central Lab, Agriculture Research Center, Egypt; Mostafa Elsayed Nanotechnology Research Centre, British University in Egypt, Egypt.

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Orcid

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First Name

Samah F.

Last Name

Darwish

MiddleName

-

Affiliation

Biotechnology Research Unit, Animal Reproduction Research Institute, Egypt.

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Orcid

-

First Name

Abeer E.

Last Name

El-Metwally

MiddleName

-

Affiliation

Immunology Unit, Animal Reproduction Research Institute, Egypt.

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Orcid

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First Name

Khaled Y.

Last Name

Farroh

MiddleName

-

Affiliation

Nanotechnology Department, Agricultural Research Center, Giza, Egypt.

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Orcid

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First Name

Adel S.

Last Name

Amin

MiddleName

-

Affiliation

Biotechnology Research Unit, Animal Reproduction Research Institute, Egypt.

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-

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-

Orcid

-

Volume

38

Article Issue

part 2 (Biological Sciences)

Related Issue

20634

Issue Date

2021-01-01

Receive Date

2021-12-26

Publish Date

2021-01-01

Page Start

183

Page End

196

Print ISSN

2356-8364

Online ISSN

2356-8372

Article File

JSRS_Volume 38_Issue part 2 (Biological Sciences)_Pages 183-196.pdf

PDF . 641.3kB

Link

https://jsrs.journals.ekb.eg/article_210692.html

Detail API

https://jsrs.journals.ekb.eg/service?article_code=210692

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Original Article

Type Code

656

Publication Type

Journal

Publication Title

Journal of Scientific Research in Science

Publication Link

https://jsrs.journals.ekb.eg/

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Article

Created At

22 Jan 2023