Coronaviruses are a large family of RNA viruses without segment, positive-sense RNA genomes and single-stranded, which cause illnesses. The disease ranging from mild in most people to diseases that is more dangerous. It may progress to pneumonia, acute respiratory distress syndrome and finally failure in vital function. Many people did not show symptoms of the disease. Clinical laboratory finding are low white cell counts with high rate of C-reactive protein. Chloroquine has positive antiviral effects on virus infection of primitive cells. In addition, these inhibitory effects were seen when the drug was used before and after exposure to the virus, this is important for both the preventive and curative architecture as well as therapeutic advantage of chloroquine. Meclizine and pyridoxine hydrochloride are considered strong anti-inflammatory, which help in controlling cytokine storm. Treatment by mixture of chloroquine, corticosterone, meclizine and pyridoxine may be protecting against blood clotting, which limits the spread of the disease. Accordingly, chloroquine, corticosterone, meclizine and pyridoxine can be used as prevention and treatment against pathogenic viral infections.