The potential synergy of combination of β-lactams(ceftriaxone, cefixime, carpabenem, and impenim)and aminoglycosides were tested against multidrug resistant Acinetobacter baumannii. Two-hundred bacterial pathogens were collected from Egyptian hospitals from various infection sites.One hundred and twentytwo isolates (60%) were resistant for aminoglycosides.Out of two-hundred strains,130 Acinetobacter baumannii strains (65%), were impenim resistant and nearly 180 Acinetobacter baumannii strains (90%),were resistant to cephalosporin. The MIC was determined for Acinetobacter baumanni istrains(32 to >512 mg/ml). In the checkerboard method, 38 combination from 45 combinations showed synergism for more than60% of the tested strains but only two  demonstrated antagonism against 5 of tested strains. i.e. the ratio of synergy were detected for gentamycin with impenim, ceftriaxone and cefixime was 100%. Also synergism observed in case of combination between amakacin and tobramycin with ceftriaxone and cefixine with 100%,but in case of combination of tobramycin with imipenem showed ratio of synergy is 50% Whereas, combination between amakacin/impenim showed antagonism .