Propolis is a natural substance known to be beneficial for human health and used as a folk medicine in many parts of the world. In this study, propolis powder was extracted by different solutions; water, hydroalcohol, ethanol and hexane and the resulted extracts were analyzed by GC/MS. All results together give evidence that the solvent used for extractions significantly affect the content of the individual compounds and each extract was associated with different number of fractions and has its own m/z range. These characteristics variation may have an impact on the biological activity of propolis.