The present study included the whole plant morphology and leaf blade anatomy of four dicot species belonging to four families; Apocynaceae, Geraniaceae, Plantagonaceae and Polygonaceae collected from east Egypt desert during three seasons in 2014, 2015 and 2016. Morphologically, the results obtained show annual habit in three species but Cynanchum acutum   found as perennial herb, all species have hairy surface. Stem ranged from erect inPlantago ovate and Rumex vesicarius toclimbing in Cynanchum  acutum and prostrate inErodium  ciconium . Anatomically, the results showed the presence of compact uniseriate epidermis, thick cuticle in all species. Trichomes varied from simple and glandular hairs in Erodium ciconium, glandular in Plantago ovate and Rumex vesicarius and absent in Cynanchum acutum.  Multilayers of palisade tissue were found in all species except Cynanchum acutum.  Calcium oxalate crystals were found as druses in all taxa except Plantago ovate. From the above results, morphologically as well as anatomically all studied species were found to be adapted to arid envinorment.