This study was conducted to investigate the effect of manganese toxicityby manganese chloride (MnCl₂) on the experimental animals and to evaluatethe efficacy of phytic acid and/orascorbic acid in attenuating the deleterious effect induced by manganese toxicity. For this purpose,thirty healthy rabbits weighing 1655±367.07g were divided into five groups each of six rabbits. Group 1; rabbits fed on commercial diet and normal water served as normal control; group 2; rabbits fed on commercial diet and received 200mg/L of MnCl₂ in drinking water. Group 3; rabbits received MnCl₂ in drinking water (200mg/L) and fed on commercial diet supplemented with phytic acid(20 g /kg diet). Group 4; rabbits fed on commercial diet and received 200mg/L MnCl₂ in drinking water and orally administrated with ascorbic acid (30mg/kg body weight daily).Group 5; rabbits received MnCl₂ in drinking water (200mg/L) and fed phytic acid (20 g /kg diet)and orally administrated ascorbic acid (30mg/kg body weight daily) by intragastric tube. Results showed that MnCl₂ intoxication significantlyreducedhaemoglobin (Hb) concentrationand serum iron with a significant increase in total iron binding capacity. Also, it induced a significant increase in malondialdehyde (MDA) level accompanied bya significant decrease in reduced glutathione (GSH) concentration and superoxide dismutase (SOD) activity. Moreover, MnCl₂intoxication caused a significant increase in serum alanine transaminase (ALT), aspartate transaminase (AST) activities. Also, serum urea and creatinine significantly elevated in MnCl_2-intoxicated group.An improvement was noticed in these altered parameters after oral administration ofphytic acid and/or ascorbic acid.