The new SARS-CoV-2 coronavirus, the origin the COVID-19 pandemic, was stated in Wuhan, China, in December 2019. It causes severe acute respiratory syndrome that leads to death. Coronavirus-2 (SARS-CoV-2) has, to date, infected more than 79 million people globally foremost to more than 1.7 million deaths and an extraordinary impact on facilities. Generally, this disease has rapidly disseminated all over the world in healthcare more than 200 countries including Egypt. To understand the impact of temperature and humidity on outbreak of this disease in Egyptian environment, this study was carried out to describe current knowledge about the appearance and speed of COVID-19 transmission. The daily recorded temperature (low and high T), and relative humidity (RH) in relation to the daily counts of COVID-19 cases in Egypt were evaluated. This study was undertaken since the data of daily infected people collected and announced daily by the Egyptian Ministry of Health and population (beginning of March till the first week of August, 2020). The results of our collected data, analyzed by using Pearson test, showed that the values of minimum temperature has significant influence on the increase of infected cases of COVID-19 (r= 0.60, n=160; p < /em>≤ 0.040). In the meantime, the multiple regression analysis revealed that the whole factors including minimum, maximum and relative humidity showed a positive significant relationship with the number of daily infected cases of COVID-19, (F. ratio= 125.375, p < /em>≤0.000). In parallel, the number of infection cases rapidly decreased with increasing in the recorded temperature, relative humidity and UV index.