Beta
ManageSearchChatDiscover
18619

The Biological Effects of Bifenthrin on T-cells and Neurons: A Comparison of Activity

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Pyrethroids are considered a less toxic class of pesticides and are therefore increasingly formulated for household use. In current study we compare the toxicity of the pyrethroid (bifenthrin) with the organochlorine (lindane) and the mitochondrial poison (rotenone) to mammalian T-cells and neurons. Cells were treated for twenty-four hours with various concentrations of pesticide and then assessed for morphology and measured for viability using trypan blue exclusion. Lindane and rotenone produced an LD50 of 500 μM and 500 nM, respectively, in T-cells and 5 μM and 250 nM, respectively, in neurons. Lindane and rotenone had a lowest observable effect level (LOEL) of 100 μM and 50 nM, respectively, in T-cells and 100 nM and 1 nM, respectively, in neurons. Significant toxicity was observed with lindane and rotenone, whereas bifenthrin did not reduce the viability of either cell type at concentrations as high as 1 mM. However, bifenthrin stimulated T-cell homotypic aggregation which is associated with cell activation. Further, bifenthrin inhibited the neurons from forming neurites. While these results support the claim that pyrethroids are less toxic than many other pesticides, they raise concerns that chronic exposure to pyrethroids could contribute to inflammation and hypersensitivity and also to developmental neurotoxicity and neurodegenerative diseases.

Keywords

Pyrethroids, bifenthrin, neurons, T-cells, neurite, toxicity

Authors

First Name

A.

Last Name

Nandi

MiddleName

-

Affiliation

Department of Biology, Adelphi University, One South Avenue, Garden City, NY 11530

Email

-

City

-

Orcid

-

First Name

D.

Last Name

Chandi

MiddleName

-

Affiliation

Department of Biology, Adelphi University, One South Avenue, Garden City, NY 11530

Email

-

City

-

Orcid

-

First Name

C.

Last Name

Thurber

MiddleName

-

Affiliation

Department of Biology, Adelphi University, One South Avenue, Garden City, NY 11530

Email

-

City

-

Orcid

-

First Name

L.

Last Name

DeLuca

MiddleName

-

Affiliation

Department of Biology, Adelphi University, One South Avenue, Garden City, NY 11530

Email

-

City

-

Orcid

-

First Name

Stephen

Last Name

Pryor

MiddleName

-

Affiliation

Neuroscience Research Institute, State University of New York, College at Old Westbury, P.O. Box 210, Old Westbury, NY 11568

Email

-

City

-

Orcid

-

First Name

A.

Last Name

McLaughlin

MiddleName

-

Affiliation

Neuroscience Research Institute, State University of New York, College at Old Westbury, P.O. Box 210, Old Westbury, NY 11568

Email

-

City

-

Orcid

-

First Name

L.

Last Name

Gibson

MiddleName

-

Affiliation

Neuroscience Research Institute, State University of New York, College at Old Westbury, P.O. Box 210, Old Westbury, NY 11568

Email

-

City

-

Orcid

-

First Name

Josephine

Last Name

Bonventre

MiddleName

-

Affiliation

Department of Biology, Adelphi University, One South Avenue, Garden City, NY 11530

Email

-

City

-

Orcid

-

First Name

K.

Last Name

Flynn

MiddleName

-

Affiliation

Department of Biology, Adelphi University, One South Avenue, Garden City, NY 11530

Email

-

City

-

Orcid

-

First Name

Benjamin

Last Name

Weeks

MiddleName

-

Affiliation

Department of Biology, Adelphi University, One South Avenue, Garden City, NY 11530

Email

weeks@adelphi.edu

City

-

Orcid

-

Volume

1

Article Issue

1

Related Issue

3877

Issue Date

2006-11-01

Receive Date

2018-11-08

Publish Date

2006-11-01

Page Start

9

Page End

14

Print ISSN

1687-5052

Online ISSN

2090-2786

Article File

CAT_Volume 1_Issue 1_Pages 9-14.pdf

PDF . 321.2kB

Link

https://cat.journals.ekb.eg/article_18619.html

Detail API

https://cat.journals.ekb.eg/service?article_code=18619

Order

2

Type

Original Article

Type Code

644

Publication Type

Journal

Publication Title

Catrina: The International Journal of Environmental Sciences

Publication Link

https://cat.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023