Chloride concentration in ground water samples was determined in ten sites of misurata zone (Sekket and Thomina areas). Sekket area considered one of the most important areas which provide Misurata city with drinking water, since Misurata zone is coastal zone and it relies on ground water as the main water source.Sixty random samples were collected from Sekket and Thomina and analysed for chloride content along with temperature,pH, electrical conductivity (E.C.) and total dissolved solids (T.D.S.)Chloride concentration detected in ground water of the studied sites varied between310.11- 819.6 mgl-1for Sekket andbetween1120.5- 2118.07 mgl-1for Thomina area. Ground water samples contain high concentration of chloride compared to WHO permissible limit. For Sekket area, it's noticed that the chloride level is relatively constant in some spots compared to previous records from 1982 to 1987.Chlorideconcentration in relation with some other physical parameters was investigated.