Macro- and micro-morphological features of seeds and pollen grains of 12 endemic taxa belonging to seven families collected from Saint Catherine area, South Sinai, Egypt were examined by light microscope (LM) and scanning electron microscope (SEM). Macro- and micro-morphological characters, of seeds including shape, colour, size, brightness, seed surface, epidermal cell shape, anticlinal boundaries, and periclinal cell wall are presented. Pollen description includes shape, size, apertures and exine ornamentation. This study presents. Seeds of eight taxa and pollen of three taxa have been described for the first time in this study.