Background: Keeping skin integrity functioning and skin barrier protection is an important aspect of nursing care. ICU patients are susceptible to various skin complications, such as pressure ulcers and moisture-related skin damage. Aim: This study aimed to pinpoint incontinence-associated dermatitis (IAD) risk determinants among ICU patients. Design: A prospective observational research design was conducted. Setting(s): Data collection was done in two general ICUs. Participants: A convenience sample of 200 intensive care inpatients was involved. Tools of data collection: One tool, "Risk Determinants of IAD tool", was used to assess the determinants contributing to IAD. It consisted of three parts, part I used to assess demographic and clinical data; part II used to assess ventilation and hemodynamic patient data, and part III used to assess skin condition. Results: About 60.5% had male gender, with a mean age of 49.51 ± 10.54, and about 69.5.% of the overall sample had IAD. Concerning the severity of IAD, 78.4% had a risk for IAD with no redness and skin intact, 19.4% were categorized as grades I, and 2.2% were categorized as grade II. Conclusion: ICU patients' exposure to several risk factors can damage their skin integrity. It can be concluded that increasing age, female gender, sepsis, neurological disorders, a high score on the perineal assessment scale, fever, hypoalbuminemia, enteral nutrition, wet skin, poor hygiene practice, and watery diarrhoea are associated risk factors for IAD in patients with a critical illness. Recommendation: Early identification and management of IAD should be early by using standardized skin protocols and skin assessment tools.