Background: Post operative nausea, vomiting, and retching are recurrent symptoms and can lead to complications ranged from mild e.g. unpleasant sensation, to severe e.g. aspiration and postpone patients' discharge. Also, the use of antiemetics accompained by side effects so, we in a great need for adding a non-pharmacological measure to routine hospital care. Aim: Explore the infleuence of deep breathing exercise on nausea, vomiting, and retching in postoperative orthopedic patients. Materials and methods: A quasi-experimental study was conducted at recovery rooms and orthopedic wards at Menoufia University Hospital, Egypt. A convenient sample of 84 patients divided into two groups control and study 42 for each, who were adult, conscious, and under general anesthesia. Three tools were used for data collection; Tool I patient information form, Tool II glasgow coma scale, Tool III index of nausea, vomiting, and retching (INVR). Results: There was a statistically significant difference in total scores of INVR between both groups after 6 hours (U (p1)=400.50* (<0.001*) and 12 hours U(p2)=529.50* (<0.001*). Conclusions: It was concluded that deep breathing exercise decreases nausea, vomiting, and retching among study group patients after both 6 and 12 hours. Recommendations: Deep breathing exercise should be added to routine hospital post operative care, and further researches on larger sample to explore frequency of antiemetic drugs use among patients performing postoperative deep breathing exercise.