Background: One of the most significant epidemics of the century, the COVID-19 virus disease is brought on by severe respiratory syndrome and poses a threat to human health globally. Study aim: to investigate the correlation between risk of diabetes and stress and cortisone regimen among patients with COVID 19. Design: It made use of a descriptive correlational design. Setting: this study was carried out at Minia Cardiothoracic University Hospital Subjects: convenient sample of 802 hospitalized patients typical COVID-19. Data collection tools: Tool (1) structured interview questionnaire, it include (socio-demographic data, medical information, laboratory investigation record and cortisone therapy monitoring). Ordinal Scale for Clinical Improvement, Type 2 diabetes risk form and Perceived Stress Scale. Results 31.3% of COVID-19 patients have low risk for type 2 diabetes, 7.5% of sample have high risk, and 52.2% of study sample use cortisone therapy < 7 days and 47% of patients suffer from severe stress. There was a high positive significant correlation among diabetes risk assessment and duration of cortisone use and level of stress. Conclusions: The data suggest that the correlation between diabetes occurrence following COVID-19 infection and diabetes risk, stress level, duration of cortisone use, and severity of the COVID-19 infection. Recommendation All COVID-19 patients should be acquire continuous glucose monitoring or to self-monitor their blood sugar levels frequently. The goal of continued monitoring is to identify pre-diabetic patients early and reduce their risk of acquiring diabetes.