Background: Alteration of the female sexual function after hysterectomy has a great concern to patients and it has negative effects on psychological health.  Aim: the current study aiming to compare between sexual function, body image and depression among women undergoing total versus partial hysterectomy. Design: The comparative correlational descriptive research design was utilized in the current study. Sample: A purposive sample of 60 participants (30 with total hysterectomy and 30 with partial hysterectomy) who admitted in outpatient clinics of gynecological department at Minia University Hospital for Maternity and Children. Tools: Four tools were utilized in this study included. A structured interview questionnaire, Female Sexual Function Index (FSFI) Scale, Body Image Scale and Beck Depression Inventory (BDI) Scale. Results: The study result reveals that the total mean scores of FSFI were 30.69±9.62 for partial versus 18.9±13.9 for total hysterectomy. Also, there were statistically significant differences between total FSFI at p= .001 and all domains. Moreover, 70% of women with partial hysterectomy are have low concern about body image; while (86.7%) total hysterectomy women are have high concern of body image. Conclusion: The current research finding concluded that women with total hysterectomy have sexual dysfunction while women undergo partial hysterectomy don't have. In addition, there were a statistically significant negative correlation between total FSFI scores with body image, and depression scores. While, there was a statistically significant positive correlation between body image and depression. Recommendation: Designing and implementing a psycho-educational program that focused on alleviating negative emotions such as depression, poor body image perception and improving sexual life through psychological rehabilitation in post-hysterectomy women.