Background: After coronary artery bypass graft surgery, considerable postoperative incisional pain is observed when incentive spirometry is used. As a result, the major postoperative treatment strategy for cardiac surgery is pain management. Localized cryotherapy is regarded as a quick, inexpensive, and non-pharmacological pain management technique. Aim: Determine the efficacy of localized cryotherapy on incisional pain associated with the use of incentive spirometry post coronary artery bypass graft surgery. Setting: Crossover study design was utilized at Cardiothoracic Surgical Intensive Care Unit (ICU) and Cardiothoracic Surgery Department at Shebin El-Kom, Menoufia University Hospital, Menoufia Governorate, Egypt. Sample: A Purposive sample of 60 adult patients were included in the study. Tools of data collection: Three tools were used for data collection; Tool I Structured interview questionnaire, Tool II Subjective pain assessment sheet, Tool III Objective pain assessment sheet. Results: There were statistically significant effects on pain intensity, pain distress, visual analog pain score, patients' perception and most of physiological indicators related to incisional pain associated with the use of incentive spirometry after localized cryotherapy application. Conclusions: Application of localized cryotherapy in form of cold gel pack application was effective for reducing incisional pain and its physiological indicators associated with incentive spirometry in patients post coronary artery bypass graft. Recommendations: For post-operative CABG patients, localized cryotherapy should be promoted as a non-pharmacological treatment option before incentive spirometry.