Background: Healthcare organization managers need to be far more nimble and adaptable to thrive in a cutthroat market. In order to foster organizational agility, administrators, managers, and leaders in the healthcare industry must provide the highest level of patient and employee needs, expectations, and demands. Organizational agility has a mediating role in fostering professional development and career goals for nurses transitioning into advanced practice, as well as improving nurses' competence (Al Humdan, Shi, and Behnia, 2020). Aim: The current study conducted to investigate the relation between organizational agility and career aspirations as perceived by staff nurses at selected hospitals. Research design: A descriptive correlational design was utilized to carry out the present study. Setting: The current study was conducted at “Gynecology, Obstetrics, and Pediatrics Minia University Hospital and at specialized pediatric Cairo University hospital. Subjects: A representative sample 30% of total number of staff nurses worked in the selected hospitals “Gynecology, Obstetrics, and Pediatrics Minia University Hospital (N= 173) and at specialized pediatric Cairo University hospital (N=110). Tools: To reach the aim of the current study, data were collected using three tools: 1st: Personal data questionnaire, 2nd: Organizational Agility Questionnaire: 3rd : Career Aspiration Scale. Results: Regarding organization agility level and career aspiration, majority of staff nurses at Specialists pediatric Cairo university Hospital reported high level of organizational agility and career aspiration while slightly more than half of staff nurses at Gynecology, Obstetric and Pediatric Minia University Hospital reported high level of organizational agility and career aspiration. There were a statistical significant difference between Specialists pediatric Cairo university hospital staff nurses and Gynecology, Obstetric and Pediatric Minia University hospital staff nurses in relation to organizational Agility and its dimension . In addition there were also a statistical significant difference between them in relation to Career aspiration and its dimension. Conclusions: it was concluded that there was a highly statistically significant correlation between total scores of organizational agility and total career aspiration. Recommendations: To enable nurses to apply their skills to achieve the work at hand and take ownership of their actions, nursing management must provide them a high level of job aspiration.