Background: Nurses have a variety roles regarding care for patients with lymphoma. They has an important role in assessing and managing many problems experienced by patients with lymphoma. Aim: This study aimed to assess nurses' performance regarding care of patients with lymphoma. Research design: A descriptive exploratory research design was utilized. Setting: Oncology unit affiliated to radiation oncology & nuclear medicine center and oncology unit at Ain- Shams Specialized Hospital, Cairo, Egypt. Subjects: A convenience sample of all available nurses (40) worked at previously mentioned settings. Tools: Three tools were used. (I) Nurse's self- administrated questionnaire. (II) Nurses' practices observational checklist. (III) Nurses' attitude scale. Results: The results of present study indicated that 65% of the studied nurses had unsatisfactory level of total knowledge while, 55% of the studied nurses were incompetent regarding their total practice. Also, 70% of the studied nurses had positive attitude towards caring of patients with lymphoma. Conclusion: less than two thirds of the studied nurses had unsatisfactory level of total knowledge regarding lymphoma. Also, more than half of the studied nurses were incompetent regarding total practice towards lymphoma. Less than three quarters of the studied nurses had positive attitude regarding caring of patients with lymphoma. Recommendations: Preparation and implementation of educational programs for nurses who are caring of patients with lymphoma to improve their knowledge and practice.