Background: Throughout the first three months following discharge from the hospital, patients who have undergone coronary artery bypass graft surgery (CABG) frequently have a wide range of symptoms, which affect the quality of life (QOL) by adding extra burdens to their health. The study aimed to determine the relationship between symptom burden clusters and the quality of life in patients with coronary artery bypass graft surgery. Research design: A descriptive correlational design was utilized in this study. Setting and sampling A purposive sample of 85 post-CABG surgery patients was investigated at the cardiac outpatient clinic affiliated with Suez Canal University Hospitals. Tools: Tool I: A structured interview questionnaire, Tool II: The cardiac symptom survey (CSS) to measure the burden of symptoms for patients who have undergone CABG surgery, Tool III: The World Health Organization Quality of Life questionnaire (WHOQOL-BREF), which measures patients' quality of life. Results: The study found that low moderate symptom burden affected 35.3% of the patients, moderate symptom burden involved 47.05%, and low symptom burden affected 17.65%. The mean score for physical health was the greatest at 62.04±11.65, followed by perceptual health at 60.24±7.93, economic health at 59.886.81, social health at 57.61±7.62, and emotional health at 55.63±7.89. Conclusion: There is a statistically significant relationship between total symptom burden and physical, social, and emotional health, and this relationship increases with every unit increase in the symptom burden score. Recommendations: Conduct research to assess how a self-care program affects patients with CABGs' symptom burden and quality of life.