Background: Osteoarthritis (OA) is a mutual advanced joint disease which is characterized by chronic pain, stiffness, and functional disability. Aim of the study: Evaluate effect of physical exercises and heat application on pain and morning stiffness in osteoarthritis patients. Study design: Quasi-Experimental design was employed to implement this study. Setting: This study was implemented at the Suez- Canal University Hospitals' orthopedic outpatient clinics. Subjects: 120 patients were included in the study as a purposive sample, while 40 patients assigned randomly into each group (control, heat and physical exercise). Data collection tools: Structured interview questionnaire to assess demographic data of patients and awareness about the disease and its management in addition to, the self- administered Knee Injury and Osteoarthritis Outcome Score (KOOS) to assess short and long-term patient-relevant outcomes following knee osteoarthritis. Results: This study revealed that (80%, 100% and 97.5%) and, (32.5%, 15%, 57.5%) of the heat, exercise, and control group had joint pain and stiffness respectively. Regarding post intervention; there was statistically significant difference between the heat, exercise and control group with 45 % of the heat group and 95% of the exercise group had moderate level of signs and symptoms. Conclusion: Heat application and physical exercises had positive effect on relieve pain, stiffness, and improvement of physical function, with heat applications had have the higher effect on symptoms. Recommendations: Using a combination of physical exercise and heat application together for patient with osteoarthritis to control pain, morning stiffness, and activity level.