Headache pain, anxiety, and Fatigue are recognized as one of the most common and distressing
adverse effects among patients with brain tumors. Aim was to evaluate the effect of the nurse-led
intervention on headache pain, anxiety, and fatigue level among patients with brain tumors.
Subjects and method: Design: A quasi-experimental research design was used to fulfill the aim of
this study. Setting: the research was conducted in the neurosurgery department at Mansoura
University Hospital. Subjects: A purposive sample of 50 adult patients was included. Four tools
were used: Tool (I) a structured interview questionnaire (II) a numerical pain rating scale, (III) a
State-Trait Anxiety Inventory, and Tool (IV) a Fatigue assessment scale. Results: The current study
revealed that there was a highly statistically significant difference and reductions in headache pain
mean scores post-nurse-led intervention at (P= <0.05). Also, the study demonstrated that there was a
highly statistically significant difference in anxiety scores post-nurse-led intervention with (P=
<0.001). Highly statistically significant differences and reductions were detected between fatigue
mean scores pre and post-nurse-led intervention with (P= <0.001). Conclusion: The nurse-led
intervention had a positive effect on headache pain, anxiety, and fatigue level among patients with
brain tumors. Recommendations: The nurse-led intervention regarding brain tumors should be
conducted, discussed, and integrated into the rehabilitation programs.