Background: Skin breakdown includes non-blanchable erythema without underlying tissue loss, abrasion, and deep and extensive pressure ulcers. Hospitalization can cause skin breakdown due to medication, food, and mobility changes. Aim: To assess the effect of skincare bundle protocol on nursing performance regarding prevention of skin breakdown. Research Design: A quasi-experimental design was used. Setting: This study was conducted in Orthopedic Surgery Departments and traumatology Departments at El Hadara Orthopedic and Traumatology University Hospital, adult intensive care units at Main University Hospital and pediatric intensive care units at El-Shatby University Hospital of Alexandria Sample: composed of 120 nurses working in the previous mentioned settings Tools tool I: Nurses' knowledge toward skin care bundle for prevention of skin breakdown. Tool II: Skin care bundle observational checklist to assess nurses' practices toward skin care bundle application. Results: A statistically significant difference in nurses' knowledge and practices about the skin care bundle between pre and post-protocol implementation was found. Conclusion: The study proved that; skincare bundle protocol improved nurses' practices toward prevention of skin breakdown. Recommendations: Publication and dissemination of the skincare bundle protocol to improve nurses' performance toward skincare to prevent skin breakdown and decrease its complications.