Herd immunity through vaccination is the target of public health interventions against COVID-19,
but vaccine refusal or hesitancy and the little knowledge available for pregnant women due to
ignorance of the vaccine's mode of action are the global threats that make the achievement of
community immunity very difficult. Aim: The study aimed to evaluate the effect of COVID19
vaccine instructional guidelines on pregnant women's knowledge and intention. Design: Quasi-
experimental research design was used in this study. Setting: It was conducted at El-fayoum
university hospital in the antenatal clinic. Sample: Convenient sample of 200 pregnant women.
Tools: structured interviewing questionnaire sheet composed of five parts to collect the following
data socio-demographic data, past obstetric history, present obstetric history, women knowledge
regarding Covid 19 vaccination and pregnant woman intention of Covid -19 vaccination. Results:
There were highly statistically significant differences between pre & post-test regarding
knowledge and intention about covid-19 vaccination and highly statistically significant between
total knowledge and intention of studied pregnant women regarding COVID-19 vaccination at pre
and post-implementation Conclusion: There was an improvement in pregnant women's
knowledge and intention regarding covid-19 vaccination post implementation of the instructional
guideline. Recommendations: implementation of public health intervention programs to alter
unfavorable beliefs and enhance Egyptians' acceptance and uptake of the COVID-19 vaccine.