Background: Helicobacter pylori (H. pylori) infection, a Gram-negative bacterium, causes 
gastrointestinal symptoms and severe complications after invading gastric mucosa. As the 
infection could be asymptomatic, it is crucial to enhance knowledge and practices of individuals 
for prevention of infection. Aim: This study aims to evaluate the efficacy of health literacy 
sessions regarding helicobacter pylori on students' knowledge and practices. Subject and 
Methods: A quasi-experimental study examined a convenient sample of 157 students at 
Damietta University hostels. The data were collected via two tools; tool I: students'
characteristics tool and tool II: structured questionnaire (pre- and post-assessment). Results:
There was a statistically significant difference in the overall mean scores of students' knowledge 
and practices between pre- and post-implementation of health literacy sessions (t =15.365, P = 
0.000); (t =13.763, P = 0.001) respectively. Moreover, there was a statistically significant 
positive correlations between students' knowledge and practices through program phases.
Conclusions and Recommendations: Screening of H. pylori for early detection should be 
applicable for most of the population. Furthermore, mass media awareness campaigns should be 
launched about preventive measures of H. pylori, and annual check-ups should be organized