Background: Cerebral palsy (CP) is a permanent disorder of posture and movement resulting from brain damage occurring in the baby or young child which could have negative impacts on social behavior of mothers Objective to assess the impacts of educational empowerment program on knowledge, aggression, loneliness, and anxiety of mothers having children with cerebral palsy. Setting; the study conducted in the pediatric department, at Minia University Hospital for Obstetrics and Pediatrics and General Hospital. Sample, Convenient samples of all available mothers who have been selected for the program pre/post the intervention. Tools: five tools were used for data collection. Tool (1) An interviewer questionnaire, (2) Buss-Perry Aggression Questionnaire (BP-AQ), (3) UCLA Loneliness, (4) Scale Beck Anxiety Inventory (BAI) and (5) Empowerment scale. Results; the finding of the current study showed that the main age of mothers was 38.2 ± 8.1years and noticeable improvement were detected in the mothers' level of knowledge, aggression, loneliness, and anxiety after implementation of the program based empowerment model compared to the pre assessment. So, the finding of this study concluded that after implementation of the intervention program-based empowerment model, mothers who had children with CP their level of aggression, loneliness and anxiety were alleviated. Recommendions: future researches are needed to develop and refine interventions through program in-order to alleviate aggression, loneliness and anxiety through empowering and engaging mothers in the caring plan of their children with CP.