Background: Despite all the efforts that have been made to fasten vaccine development
many critical care nurses staff were worried and hesitated from the vaccine. Aim of the study: is to
assess critical care nurses perception of covid-19 vaccines and its side effects at Upper Egypt.
Sample: 2429 critical care nurses from five Upper Egypt Governorates, Minia, Assiut, Sohage,
Qena and Aswan. Tools: the study included two tools, Critical Care Nurses' knowledge
questionnaire and Critical Care Nurses' attitudes toward COVID-19 vaccine. Result: the included
ICU's nurses 88.4% of them were under the age of 29 years, and 57.8 % had a technical institute of
nursing. Regarding to the nurses' knowledge it was noticed that 79.5 % of the nurses believed that
taking COVID-19 vaccine did not provide protection. But 55.2 % critical care nurses had positive
attitude toward COVID-19 vaccines. Regarding to the vaccines side effects, sit pain, swelling fever
and redness were the most reported manifestations among nurses. Conclusion: critical care nurses
had positive attitude about COVID-19 vaccine but hesitated to be vaccinated because of the fear
from its side effect. Recommendations: Future research evaluating the side effects of all types
covid -19 vaccines in all Egypt.