Background: Substanceabuse disorder is a dangerous problem that is enough to interfere with the quality of life of the person, family, and society. It negatively affects the socio-economical, cultural aspects, and organization of our community Aim: This study aimed to determine the effectiveness of psychological intervention for patients with substance abuse on their self-efficacy, self-control, and coping patterns. Research design: A quasi-experimental study was utilized. Setting:  This study was conducted at the outpatient clinic affiliated to Abbassia Mental Health Hospital. Subjects: a purposive sample of 60 patientswith substance abuse disorders from the previously mentioned setting. Tools: 1) An interview questionnaire to assess socio-demographic characteristics and knowledge among studied patients with substance abuse disorders2) Practical skills measured by Behavior and Symptom Identification Scale, and 3) Drug Abstinence Self-Efficacy Scale, 4) Brief Self-Control Scale, 5) Coping Behaviors Inventory. Results: The study revealed that there were statistically significant differences between the pre-and post-psychological intervention in all study variables; knowledge (P Value= 0.01), Behavior and Symptom Identification Scale, Drug Abstinence Self-Efficacy Scale, Brief Self-Control Scale, and Coping Behaviors Inventory (P Value= 0.05).Conclusion: The psychological intervention has effective and positive outcomes in self-control behaviors, self-efficacy, and coping patterns among patients with substance abuse disorders. Recommendation: Conduct experimental and longitudinal research to evaluate the effectiveness of the psychological intervention in improving self-efficacy, self-control behaviors, and coping strategies.