Background: Organizational agility is a conscious and weighted answer to unpredictable and continual changes in the environment, which enables hospitals to continue to grow and develop in a competitive environment. The core competency of agile organizations is to be able to operate successfully in a dynamic and changing environment to enrich job of nurses. Aim: The study aimed to assess the relation between organizational agility and job enrichment as reported by nurses. Research Design: Descriptive correlational research design was utilized. Setting: The study was conducted at Benha University Hospitals in all medical and surgical departments. Sample: The convenience sample consisted of 250 nurses who worked were randomly selected in the previously mentioned setting. Tools of data collection: Two tools were used; (I): Organizational Agility Questionnaire, (II): Job Enrichment Questionnaire. Results: The findings of this study showed that (65.2%) of nurses reported that organizational agility level was moderate and (57.2%) of nurses reported that job enrichment level was moderate. Conclusion: There was a highly statistically significant correlation between total scores of organizational agility and total job enrichment. Recommendations: Hospital administrators need to create specialized teams and offer seminars and workshops in order to attain speed, flexibility, reactivity, adaptability and group activities and participation culture among nursing staff. Nursing managers need to provide nurses a high degree of job autonomy to allow them to use their abilities to complete the assigned task and accept responsibility for their actions.