Background: Standards precautions are designed to protect staff from risks resulting from
exposure to blood and body fluids and to protect patients from potential cross infection. Knowledge
of clinical infection control practices is continually growing and changing. Therefore, the aim of the
study was to assess nurses' performance regarding infection control precautions in primary health
care centers. Research design: a descriptive analytical design had been used. Subjects: simple
random sample of a total of 379 nurse was recruited from the 1st of June 2019 to the first of
December 2019, at selected primary health care centers affiliated to health affairs directorate in Kafr
El-Sheikh governorate according to large number of nurses. Tools of data collection: three tools
were used to collect data: a structured self- administrated nurses' questionnaire, observational check
list, and environmental assessment checklist. Results: the results revealed that 44.6% of the studied
nurses had average level of total knowledge, whereas 58.6% of them had incompetent practice
regarding infection control precautions. Moreover, there was highly statistically significant positive
linear correlation between total nurse`s knowledge about infection control precautions in primary
health care centers and their practice at (r = 0.317, and p =0.000). In conclusion, Based on the
findings of this study, it can be concluded that, more than one third of nurses in the current study
had average overall knowledge score, while more than one half of them had incompetent practice
regarding infection control precautions. A highly statistically significant positive linear correlation
between total nurses' knowledge about infection control precautions in primary health care centers
and their practice was pointed up. Recommendations: mandatory regular base educational program
must be planned to overcome the weak level of knowledge and updated and the nursing practice
regarding infection control standard precautions.