Background: Due to the debilitating effects of severe labor pains, its management continues to be an essential subject that needs much attention. Application of a non- pharmacologic solution could have a significant impact on nursing practice to reduce labor pain and anxiety. Aims: To compare the effect of virtual reality and chewing mint gum on labor pain intensity and anxiety level. Methods: This is a single-blind, three-group clinical trial study on 300 mothers affiliated to Beni Suef University Hospitals and Elnada maternity and Plastic surgery hospital for natural childbirth during the year 2021 -2022. Subjects: were randomly divided into three groups of chewing gum, virtual reality, and control using six blocks. Group one (Chewing gum interventions), group two (virtual reality) where dilatation for 20 min were performed twice in 4–5 cm and 7–8 cm. Group three is the control group, where nurses performed the routine hospital care only. Tools: included A structured interviewing Questionnaire, Numerical rating scale, Visual anxiety scale or Observational scale of behavioral distress and mothers` satisfaction Questionnaire. Results: There was differences in pain intensity and anxiety level before and after the intervention. There was significant difference between pre-intervention pain intensity and anxiety level scores among the three studied groups, but there was a significant difference between pain intensity and anxiety level scores immediately and after 30 min post the intervention implementation. Conclusion: The results of this study displayed that virtual reality and chewing mint gum as an intervention decrease pain intensity and anxiety level during the first stage of labor. Recommendations: for further research include a larger sample, long-term retention, and opinions pregnant women.