Introduction: According to the World Health Organization (WHO), coronavirus disease (COVID-
19) had become the global concern as public health emergency. Cases are increasing as alarming
rate. WHO also reported that prognosis of COVID-19 remains mostly unknown. Aim: This study
aimed to assess risk perceptions for Covid-19 among individuals with chronic diseases pre- post
COVID -19 Vaccination Announcement. Research design: exploratory comparative research
design was employed to achieve the study objectives. Setting: The study was conducted at cardiac
and diabetic outpatient clinics at Alexandria Main University Hospital, Egypt. Subjects: The study
included random sample of 80 adult patients from both genders diagnosed as cardiovascular
disorders, Diabetes Meletus, or both, who are admitted to the above-mentioned settings were
included in the study. Tools: two tools were used for data collection; tool I- Patient Demographic
characteristics and clinical data, tool II- perception of COVID 19 risk. Results: this study shows
that the highest percentage of studied patients had high risk perception pre-post vaccination
announcement. Also results revealed that more than half of studied patients agree with such
statement " If the individual receive the vaccine, he leaves the precautionary measures and live a
normal life" pre - post vaccination announcement. Conclusion: This study concluded that the
highest percentage of studied patients had high risk perception pre COVID-19 vaccination
announcement while all studied patients had high risk perception post vaccination announcement.
Recommendations: Replication of the study on large probability sampling is require.