Background: Iliotibial band friction syndrome is a common injury of lateral outer aspect of knee particularly in active people. Aim: Examined the effect of home exercises on clinical and functional outcomes of patients with iliotibial band friction syndrome. Patients and methods: Research design: Randomized controlled trial which is a true experimental design where patients are randomly allocated to groups. Sample and setting: Sixty-two adult patients with iliotibial band friction syndrome for more than 2 weeks attended to orthopedic department and orthopedic outpatients clinic at Assiut University hospitals. A computer based selection program was used to assign patients randomly into 2 equal groups (exercises group n=31) and (control group n=31) with ratio 1:1 assignment. Exercises group participated in home exercises (educational brochure) for stretching iliotibial band and strengthening hip abductors; while control group did not. Patients followed up for 8 weeks. Tools: patients assessment sheet, numeric pain rating scale, lower extremity functional scale and training schedule for exercises group patients (logbook). Results: Pain level of exercises group significantly decreased in intermediate (p. value 0.04) and final measurements (p. value 0.001) than control group. The mean scores of lower extremity functional scale for exercises group increased significantly in intermediate (p. value 0.02) and final measurements (p. value < 0.001) than control group < strong>. Conclusion: Home exercises for stretching iliotibial band and strengthening of hip abductors decreased pain and improved lower extremity function. Recommendation: Home exercises educational brochure have to be used by rehabilitation nurses as a guide in rehabilitation of patients with iliotibial band friction syndrome.