Background: Osteogenesis Imperfecta (OI) known as brittle bone disease, it is a
genetic disorder of connective tissue which is characterized by bones that fracture easily
from little or no apparent trauma. However, the multiple fractures will lead to progressive
bone deformities, short stature and restricted mobility. This study aimed to assess mothers,
role regarding care of their children suffering from OI. Research design: A descriptive design
was utilized. Setting: The study was conducted at Genetic Department in Children Hospital
affiliated to Ain Shams University Hospitals. Subjects consisted of 80 mothers accompanying
their children suffering from OI. Tools: Data were collected through using. Tool (1):
Interviewing questionnaire tool it was consisted of: Part 1: Characteristics of the study subjects.
Part 2: Knowledge of mothers regarding to OI. Tool (2): mothers, reported practices regarding to
care of their children suffering from OI. The results of the study revealed that, the mean age of
studied mothers was 32.82±5.3 years; the mean age of the studied children was 8.14±5.71years.
Majority of studied mothers had negative family history of OI. Also, less than two thirds of them
had consanguinity relation. Conclusion: This study concluded that less than half of the studied
mothers had satisfactory knowledge and less than half of them had adequate reported practices
regarding to care of their children suffering from OI. Recommendation: Educational program
intervention should be conducted for mothers of children with OI to raise their level of knowledge
and practicesregarding caring of their children with OI.