Background: Early identification of women at risk may help in prevention of preeclampsia and complications of this disease. Aim of study: the study aimed to assess prevention of preeclampsia among pregnant women in the second trimester. Subjects and methods: Design: Descriptive exploratory research design. Setting: The study was conducted at the selected maternal and child health centers affiliated to the Beni-Suef governorate, El-Wasta center that include 24 MCH centers. Sample: Purposive sample of 550 pregnant women was used. Tools: Two data collection tools were used to carry out the current study namely; Interviewing questionnaire tool, include Part I: concerned with demographic characteristics of the pregnant women. Part II: Assess pregnant women's knowledge about pre-eclampsia Part III: Assess indicators of pre-eclampsia among pregnant women. Part IV: Assess pregnant women's practices about the prevention of pre-eclampsia and risk factors assessment tool. Results: 56.8% of the pregnant women have unsatisfactory total knowledge about preeclampsia. Also, 91.8% of the pregnant women have satisfactory total practices regarding preeclampsia. 83.8% of them had normal body mass index as risk factor of preeclampsia and 98.8% of them had edema in their feet as indicator of preeclampsia. Conclusion: More than half of the pregnant women have unsatisfactory total knowledge about preeclampsia. Also, most of the pregnant women have satisfactory total practices regarding preeclampsia. Majority of the pregnant women had normal blood pressure as indicator of preeclampsia. Majority of the pregnant women had normal body mass index as risk factor of preeclampsia. Recommendations: Providing sufficient training for women regarding pre-eclampsia to enhance their knowledge, providing sufficient training for women regarding pre-eclampsia to enhance their performance.