Background: The care of the women undergoing hysterectomy should meet both their physical and psychological needs, and this must involve their families. However, psychological care such as the provision of sound information, emotional support, and advice, is often missed. Aim: To evaluate the effect of social media-based teaching program on emotional status and quality of life for women undergoing hysterectomy during Covid-19 lockdown.  Methods: Subjects and method: Design: Quasi-experimental research design pre-post-test was used. Settings: The study was conducted at Mansoura City in Egypt. Sample: A purposive sample of 400 women having a hysterectomy was obtained from social media such as Facebook and WhatsApp groups, 2020 which the online Google form spreadsheet was opened from the third day of May 2020 to 23 May 2020 it was closed. Three tools used in data collection: (I): A self-administered questionnaire (pre and post-test format) to assess women's demographic characteristics, obstetric, and medical histories; women's knowledge about hysterectomy (pre and posttest format); (II): Depression, Anxiety, and Stress Scale (DASS); and (III): Quality of Life (QoL) scale. Results: The present study revealed that there were highly statistically significant differences between women's knowledge and their depression, anxiety, and stress levels regarding hysterectomy at the COVID-19 pandemic outbreaks pre and post-implementation of the social media-based teaching program. Also, Significant improvements in the QoL (p < 0.001) were revealed after the implementation of the social media-based teaching program. Conclusion: the study concluded that social media-based teaching program implementation achieved significant improvements in the women's knowledge has a positive effect on improving the emotional disturbance as depression, anxiety and stress, and quality of life among undergoing hysterectomy women during the covid-19 lockdown. Recommendations: The social media-based teaching program should be applied and carefully planned for all women undergoing hysterectomy as a new teaching method for proving health issues.